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Infants meeting all entry criteria received either Curosurf or Survanta within four hours of the qualifying decompensation and again 12 hours later. Oxygen, ventilatory parameters, blood gas results and tracheal aspirate samples were collected prior to, and 12 and 24 hours after dosing. Twenty neonates qualified for secondary surfactant administration and 10 had tracheal aspirates collected at the 3 time points. There were trends toward decreasing pro-inflammatory cytokines after surfactant administration. Surfactant dosing seemed to disrupt the correlation of pro-inflammatory cytokines, suggesting that inflammatory cytokines are affected differently, plan i business buy a can. The Respiratory Severity Score (RSS) and Modified Ventilatory Index (MVI) have been studied in this group of infants. The ability to use clinical data in an objective scoring system that correlates with the inflammatory process in the lungs would sociology homework help advantageous in deciding can i buy a business plan and which treatment options were most appropriate. Based on this study, MVI scores seemed to be a better indicator of changes in inflammatory mediators, and maybe a better predictor of on-going inflammation and risk of CLD. Further randomized controlled trials are needed to confirm these preliminary results.

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